Table 3: Treatment of NAFLD by insulin sensitising agents.

Author, year	Number of cases	Study type	Duration of treatment	Outcome
METFORMIN
Marchesini, 2001	20	Controlled against treatment refusals	4 months	Decrease in ALT
				Reduced liver volume
Uygun, 2004	17	RCT vs diet alone	6 months	Decrease in ALT
				No histological improvement
Nair, 2004	15	Observational	12 months	No benefit
Tiikkainen, 2004	11	RCT	4 months	No reduction in liver fat
				Improved hepatic IR
Bugianesi, 2005	55	RCT vs diet or vitamin E	12 months	Decrease in ALT
				Limited histological improvement (Metformin arm)
THIAZOLIDINEDIONES
Caldwell, 2001	10	Observational	6 months	Decrease in ALT
				No histological improvement
Neuschwander-Tetri, 2003	25	Observational	12 months	Decrease in ALT
				Histological improvement
Promrat, 2004	18	Observational	12 months	Decrease in ALT
				Histological improvement
Tiikkainen, 2004	9	RCT	4 months	Decrease in liver fat
				Improved hepatic IR